Liv Pure vs HepatoBurn 2026: Which Liver-Focused Weight Loss Supplement Wins?
If you’ve been comparing Liv Pure and HepatoBurn, here is the short answer: Liv Pure is the stronger choice for most people — its two-complex formula addresses both liver purification and fat metabolism, it carries a higher ClickBank gravity (32.6 vs 18.7), and its ingredient panel is better documented in clinical literature. HepatoBurn takes a narrower thermogenic angle that may suit a specific buyer, but Liv Pure’s broader mechanism and more established track record make it the default recommendation for anyone looking to support liver health while pursuing weight loss.
That said, this is not a forgone conclusion. Both products share the same vendor, the same 60-day guarantee, and the same core thesis — that a sluggish or overburdened liver is a root cause of stubborn weight gain. The differences come down to formula philosophy, ingredient depth, and which phase of the problem each product targets. This comparison breaks all of that down so you can decide with confidence.
TL;DR — Quick Verdict
- Liv Pure wins on ingredient breadth: two distinct complexes (purification + fat-burning) vs HepatoBurn’s single thermogenic approach
- Liv Pure’s ClickBank gravity (32.6) is nearly double HepatoBurn’s (18.7), indicating stronger real-world demand
- Both carry 60-day money-back guarantees and are manufactured in FDA-registered, GMP-certified US facilities
- Choose Liv Pure if liver detoxification is your priority; consider HepatoBurn only if you specifically want a narrower thermogenic-liver focus
Ratings at a Glance
| Liv Pure | HepatoBurn | |
|---|---|---|
| Overall | ★★★★☆ 4.2/5 | ★★★¾☆ 3.8/5 |
| Ingredient Quality | ★★★★☆ | ★★★☆☆ |
| Formula Transparency | ★★★★☆ | ★★★☆☆ |
| Value for Money | ★★★★★ | ★★★☆☆ |
| Refund Policy | ★★★★★ | ★★★★★ |
| Market Credibility | ★★★★☆ | ★★★☆☆ |
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1. Quick Comparison Overview
Before diving into the details, here is a side-by-side snapshot of both products.
| Feature | Liv Pure | HepatoBurn |
|---|---|---|
| Primary mechanism | Liver purification + fat-burning dual complex | Thermogenic liver fat activation |
| Key ingredients | Silymarin, Betaine, Berberine, Molybdenum, Glutathione, EGCG, Resveratrol, Genistein, Chlorogenic Acid, Choline | Thermogenic/hepatic blend (proprietary) |
| Form | Capsules (2/day) | Capsules |
| Single-bottle price | $69 | ~$59–69 |
| Best-value price | $39/bottle (6-pack) | Similar multi-bottle discount |
| Guarantee | 60-day money-back | 60-day money-back |
| Vendor | Jvwithae (ClickBank) | Jvwithae (ClickBank) |
| ClickBank gravity | 32.6 | 18.7 |
| Manufacturing | FDA-registered, GMP-certified | FDA-registered, GMP-certified |
| Who it’s best for | Liver burden + fat metabolism support | Primarily thermogenic liver fat targeting |
The core finding is that these are more complementary than competitive — they attack the liver-weight connection from different angles. The question is which angle matches your situation.
2. The Shared Premise: Why Liver Health Matters for Weight Loss
Both Liv Pure and HepatoBurn are built on the same foundational claim, and it deserves scrutiny before we evaluate which product delivers it better.
The liver is the body’s primary metabolic organ. It processes every fat molecule you ingest, regulates glucose storage, filters toxins, and produces bile for fat digestion. When the liver is overburdened — by processed foods, excess alcohol, environmental toxins, or metabolic stress — its fat-processing efficiency declines. Fat can accumulate in liver cells (hepatic steatosis, colloquially known as fatty liver), and the organ’s ability to convert stored fat into usable energy slows down.
This is not fringe science. Non-alcoholic fatty liver disease (NAFLD) affects roughly one in four adults globally, and it is strongly correlated with obesity and metabolic syndrome. What is more debated is whether a supplement can meaningfully improve liver function in an otherwise healthy person, or one with sub-clinical liver burden, in ways that produce detectable weight loss.
The honest answer: the research supports several of the ingredient categories used by both products (silymarin, berberine, EGCG, chlorogenic acid) for liver enzyme normalization, hepatic fat reduction, and metabolic improvement — but results are dose-dependent, baseline-dependent, and almost always studied alongside dietary changes, not as standalone interventions.
That context matters for this comparison. Neither Liv Pure nor HepatoBurn is a magic bullet. But within the category of liver-supportive weight loss supplements, the formula composition, ingredient quality, and clinical backing vary — and that is exactly where Liv Pure pulls ahead.
For a broader look at why liver function matters in the weight loss conversation, see our piece on Gut Health and Weight Loss and Best Weight Loss Supplement Ingredients.
3. Liv Pure: Mechanism and Formula Analysis
Liv Pure’s design philosophy is the most distinctive aspect of this comparison. Rather than simply piling metabolic-support ingredients into a single blend, Liv Pure separates its formula into two named complexes with distinct functional goals.
The Liver Purification Complex
This is the first complex and, in the product’s logic, the prerequisite step. Before the body can efficiently burn fat via the liver, the liver needs to be operating cleanly. The purification complex includes:
Silymarin (from milk thistle): The most extensively researched hepatoprotective compound in natural medicine. Silymarin functions as both an antioxidant and an anti-inflammatory agent specifically within liver cells. Multiple randomized controlled trials have shown silymarin can reduce liver enzyme levels (ALT, AST) in patients with non-alcoholic fatty liver disease, and animal studies demonstrate it reduces hepatic fat accumulation. For a weight loss supplement, its relevance is in restoring normal liver metabolic activity.
Betaine (trimethylglycine): A methyl donor that supports the liver’s methylation processes. Betaine has been shown in clinical trials to reduce hepatic fat content in patients with non-alcoholic steatohepatitis (NASH), the more advanced form of fatty liver disease. It also supports bile production, which is essential for dietary fat digestion.
Molybdenum: A trace mineral that serves as a cofactor for four key enzymes involved in toxin breakdown, including sulfite oxidase and xanthine oxidase. Its inclusion in the purification complex reflects the product’s detoxification angle — molybdenum helps the liver clear sulfur-containing compounds that accumulate from processed food intake.
Glutathione: Often called the body’s “master antioxidant,” glutathione is synthesized in the liver and is central to Phase II detoxification — the process by which the liver conjugates toxic compounds for excretion. Supplemental glutathione has bioavailability challenges (it is degraded in the gut), but liposomal and acetylated forms are increasingly used in clinical contexts, and precursor supplementation (e.g., NAC) is well-validated. Liv Pure’s inclusion of glutathione directly, rather than a precursor, is a reasonable choice for general wellness purposes.
The Fat-Burning Complex
Once the liver purification groundwork is laid, Liv Pure’s second complex targets the metabolic output side:
EGCG (Epigallocatechin gallate, from green tea): The most studied catechin in fat-burning research. EGCG inhibits catechol-O-methyltransferase (COMT), an enzyme that breaks down norepinephrine, allowing norepinephrine to stimulate fat cell breakdown for longer. Meta-analyses consistently show EGCG produces modest but real reductions in body weight and fat mass, particularly abdominal fat.
Resveratrol: A polyphenol from red grapes and Japanese knotweed. Resveratrol activates SIRT1 (sirtuin 1), a protein that regulates cellular energy metabolism and has been shown in animal models to mimic some effects of caloric restriction. Human studies show more modest effects, but resveratrol is well-supported for its anti-inflammatory and metabolic-support properties.
Genistein: An isoflavone from soy with documented effects on adipogenesis (fat cell formation) — specifically, it inhibits the differentiation of pre-adipocytes into mature fat cells. Genistein also has mild estrogenic activity, which is relevant context for users with hormone sensitivities.
Chlorogenic Acid (from green coffee bean): Reduces glucose absorption in the gut by inhibiting glucose-6-phosphatase, lowering post-meal blood sugar spikes that would otherwise trigger fat storage. Its inclusion alongside EGCG creates complementary metabolic coverage.
Choline: An essential nutrient for fat transport. Choline is required to produce phosphatidylcholine, the molecule that packages fat into very low-density lipoproteins (VLDL) for export from the liver. Choline deficiency is actually a well-documented cause of hepatic fat accumulation, making its presence in a liver-focused formula mechanistically sound.
For a full deep-dive on Liv Pure’s ingredient panel, see our Liv Pure Side Effects and Ingredients review, and for how the product performs in practice, see Does Liv Pure Really Work?
4. HepatoBurn: Mechanism and Formula Analysis
HepatoBurn’s name signals its mechanism directly: hepato (liver) + burn (thermogenic). Where Liv Pure’s two-phase approach separates purification from fat burning, HepatoBurn collapses those into a single thermogenic-liver activation model.
The core premise is that thermogenic compounds can specifically stimulate the liver’s fat-oxidation pathways, causing the liver itself to generate heat while processing stored fat. This is an extension of standard thermogenic supplementation logic, applied specifically to hepatic fat metabolism rather than systemic metabolism.
HepatoBurn’s formula is less publicly documented than Liv Pure’s at the individual-ingredient level, which is a transparency consideration. Based on available product information, the formula emphasizes thermogenic compounds that interact with hepatic metabolic pathways — compounds in the stimulant and plant-extract family that increase cellular energy expenditure.
The approach has merit in theory. The liver is a highly thermogenic organ under normal conditions — it generates a significant portion of the body’s resting heat production through its metabolic activity. Targeting this thermogenic activity directly, rather than first going through a purification stage, is a valid alternative model.
What HepatoBurn does well:
- Direct thermogenic approach means faster perceived activation — users seeking immediate metabolic boost may notice this more acutely than Liv Pure’s two-phase purification approach
- Liver-targeting framing is coherent and mechanistically grounded
- Same 60-day guarantee and ClickBank infrastructure as Liv Pure means equivalent purchase protection
- Manufactured under the same vendor quality standards (FDA-registered, GMP-certified facilities)
Where HepatoBurn falls short:
- The formula’s individual ingredient transparency is lower than Liv Pure’s, making it harder to evaluate dose adequacy
- The ClickBank gravity of 18.7 — while not low — is meaningfully behind Liv Pure’s 32.6, suggesting less real-world adoption
- The narrow thermogenic angle means it does not address the detoxification side of liver burden, which for many users is the more relevant underlying issue
- No named complexes or documented dual-mechanism approach means the formula architecture is less differentiated
5. Ingredient-by-Ingredient Comparison
This table compares the documented ingredients of both formulas against their clinical evidence base.
| Ingredient | Present in Liv Pure | Present in HepatoBurn | Clinical Evidence for Liver/Weight | Notes |
|---|---|---|---|---|
| Silymarin (Milk Thistle) | Yes | Not documented | Strong — RCTs for hepatoprotection, ALT/AST reduction | Liv Pure advantage |
| Betaine | Yes | Not documented | Moderate-Strong — RCTs for NASH, hepatic fat reduction | Liv Pure advantage |
| Molybdenum | Yes | Not documented | Supportive — cofactor for detox enzymes | Liver detox support |
| Glutathione | Yes | Not documented | Supportive — master antioxidant, Phase II detox | Bioavailability variable |
| EGCG (Green Tea) | Yes | Possible (thermogenic blend) | Strong — multiple meta-analyses for fat loss | Widely studied |
| Berberine | Yes | Possible (thermogenic blend) | Strong — blood glucose, lipid profile, AMPK activation | Also anti-diabetic effect |
| Resveratrol | Yes | Not documented | Moderate — SIRT1 activation, anti-inflammatory | Animal data stronger than human |
| Genistein | Yes | Not documented | Moderate — anti-adipogenic, metabolic support | Mild estrogenic; note for sensitive users |
| Chlorogenic Acid | Yes | Not documented | Moderate — glucose absorption inhibition | Green coffee bean extract |
| Choline | Yes | Not documented | Strong — essential for hepatic fat export; deficiency causes fatty liver | Mechanistically important |
| Thermogenic blend | Partial (EGCG + Berberine) | Yes (core formula) | Variable — depends on specific compounds | HepatoBurn strength |
Across this comparison, Liv Pure documents ten named, individually studied ingredients. HepatoBurn’s thermogenic blend may overlap with some of these compounds, but the lack of individual ingredient documentation means it cannot be scored with the same confidence.
For context on how individual ingredients like these perform across multiple supplement categories, see Best Weight Loss Supplement Ingredients.
6. Pricing Comparison
Both Liv Pure and HepatoBurn operate within the standard ClickBank supplement pricing model. Here is how Liv Pure’s pricing tiers break down, which represent reasonable benchmarks for the category:
| Liv Pure Package | Price Per Bottle | Total | Shipping |
|---|---|---|---|
| 1 bottle (30-day supply) | $69 | $69 | Standard shipping applies |
| 3 bottles (90-day supply) | $49 | $147 | Reduced |
| 6 bottles (180-day supply) | $39 | $234 | Free |
HepatoBurn operates in a similar $59–69 single-bottle range with comparable multi-bottle discounts, though exact tiers may vary. Because both are ClickBank products, the checkout, payment processing, and refund mechanisms are identical.
Value analysis:
For a 3–6 month commitment — which is the realistic minimum to assess any liver-support supplement — the Liv Pure 6-bottle package at $39/bottle with free shipping represents the strongest value proposition in this comparison. At that price point, the per-day cost drops to approximately $2.60, which is competitive with standalone milk thistle supplements, standalone berberine products, or EGCG supplements purchased individually.
HepatoBurn’s pricing offers similar multi-bottle economics, but given the formula transparency gap and lower gravity, Liv Pure’s value equation is stronger.
Both products are covered by 60-day money-back guarantees through ClickBank, meaning the financial risk of trying either is effectively zero within the first two months. This is a meaningful consumer protection that makes a 3-month supply a low-risk entry point.
For current discount availability on Liv Pure, see our Liv Pure Pricing page.
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7. Side Effects Comparison
No supplement is without potential side effects, and liver-focused formulas in particular deserve careful consideration given the organ they are targeting.
Liv Pure Side Effect Profile
Berberine is the ingredient most likely to cause noticeable side effects in Liv Pure. At higher doses, berberine can cause gastrointestinal discomfort — nausea, cramping, or loose stools — particularly when taken on an empty stomach. It also meaningfully affects blood glucose levels through AMPK pathway activation, which is valuable for metabolic support but requires caution in people on diabetes medications or those with hypoglycemia risk.
Genistein carries mild estrogenic activity as an isoflavone. For most users this is not clinically significant, but users with estrogen-sensitive conditions (certain breast cancers, endometriosis) or those on hormone therapy should consult a physician before use.
Silymarin is one of the best-tolerated compounds in the hepatoprotective category. Side effects are rare and generally limited to mild gastrointestinal symptoms at very high doses.
EGCG from green tea can cause jitteriness or sleep disruption in caffeine-sensitive individuals, though the caffeine content of standardized EGCG extracts varies. Confirm the specific form in the Liv Pure label.
Chlorogenic acid can cause mild gastrointestinal symptoms in sensitive individuals, similar to drinking strong coffee on an empty stomach.
Overall, Liv Pure’s side effect profile is consistent with a well-formulated botanical supplement. The most relevant cautions are for berberine-drug interactions and genistein for hormone-sensitive conditions. See our dedicated Liv Pure Side Effects and Ingredients review for the full safety analysis.
HepatoBurn Side Effect Profile
HepatoBurn’s thermogenic orientation means its side effect profile may skew more toward stimulant-class effects: increased heart rate, elevated blood pressure, jitteriness, or sleep disruption — depending on the specific compounds in its blend. Because the ingredient list is less publicly documented at the individual compound level, this is harder to characterize precisely than Liv Pure’s profile.
Users with cardiovascular conditions, anxiety disorders, or stimulant sensitivity should be more cautious with thermogenic-primary formulas like HepatoBurn than with Liv Pure’s more botanically balanced approach.
General guidance for both products:
- Start with the recommended dose; do not exceed it
- Take with food to reduce GI side effects
- Do not combine with other stimulants or liver-active supplements without medical guidance
- Stop use and consult a healthcare provider if you experience unusual fatigue, dark urine, or abdominal pain (these could indicate a liver response requiring evaluation)
- Consult your physician if you are on blood thinners, diabetes medications, hormone therapy, or any chronic medication
8. Who Should Choose Liv Pure?
Liv Pure is the right choice if any of the following describe you:
You want a two-phase formula that addresses root cause before optimization. Liv Pure’s purification complex (silymarin, betaine, molybdenum, glutathione) is specifically designed to reduce liver burden before the fat-burning complex activates metabolic output. If you believe your liver is overburdened — by a history of processed food consumption, alcohol use, or environmental toxin exposure — this sequenced approach is more relevant than HepatoBurn’s direct thermogenic push.
You want ingredient-level transparency. Liv Pure names each ingredient in its two complexes. You can independently look up the clinical evidence for silymarin, berberine, EGCG, resveratrol, and each other compound. That level of transparency is a meaningful quality signal.
You want the supplement with the stronger market validation. Liv Pure’s ClickBank gravity of 32.6 — nearly double HepatoBurn’s 18.7 — indicates stronger real-world sales velocity and customer demand. Gravity is an imperfect metric, but it does reflect actual consumer behavior across the ClickBank marketplace.
You want the most cost-effective per-ingredient value. At $39/bottle on the 6-pack, Liv Pure delivers ten named, clinically studied ingredients at a price comparable to buying two or three individual supplements.
You’ve already read reviews and testimonials. See Liv Pure Real Reviews for a curated look at what verified purchasers report, and Liv Pure for Weight Loss for a deeper analysis of the weight loss mechanisms specifically.
For a comprehensive evaluation of the product, our full Liv Pure Review 2026 covers all dimensions from efficacy to sourcing.
9. Who Should Choose HepatoBurn?
HepatoBurn may be the better fit in a narrower set of circumstances:
You specifically want thermogenic liver activation over detoxification. If your liver is not particularly burdened (you eat cleanly, drink minimally, live in a low-toxin environment) and your primary goal is accelerating hepatic fat burning rather than first clearing liver-level obstacles, HepatoBurn’s more direct thermogenic approach targets that goal more narrowly.
You have previously used Liv Pure without satisfying results. Different formula philosophies can produce different individual responses. If Liv Pure’s two-phase approach did not deliver what you expected, HepatoBurn’s thermogenic angle offers a meaningfully different mechanism to try — without abandoning the liver-focus concept entirely.
You prefer a simpler formula. Fewer named compounds means fewer potential interactions for users who are managing multiple supplements or medications. If your supplement stack is already complex, HepatoBurn’s narrower formula may integrate more cleanly.
However, be aware that HepatoBurn’s thermogenic emphasis also means a higher likelihood of stimulant-class side effects compared to Liv Pure’s more botanical, less stimulant-heavy composition. For users exploring the intersection of liver health and thermogenics more broadly, our Thermogenic vs Appetite Suppressant overview provides useful category context.
10. Our Pick and Why
Liv Pure is the recommendation for the majority of readers comparing these two products.
The decision comes down to four factors that consistently favor Liv Pure:
Formula depth. Ten named, individually documented ingredients across two purpose-built complexes versus a less-transparent thermogenic blend. When you can trace each ingredient to peer-reviewed research, you can evaluate the formula rationally. When you cannot, you are trusting the label more than the science.
Mechanistic completeness. The two-complex architecture — purification first, fat-burning second — reflects a more realistic model of how liver dysfunction and metabolic slowdown interact. Trying to accelerate fat burning from a liver that is still processing a significant toxin or inflammatory load is like pushing a car with the parking brake engaged. Liv Pure’s design releases the brake before pressing the accelerator.
Market signal. A ClickBank gravity of 32.6 is not the highest in the weight loss supplement category, but it is a credible indicator that Liv Pure has converted customers at a meaningful scale and retained them well enough to sustain ongoing sales. HepatoBurn’s gravity of 18.7 is not negligible, but the gap is significant.
Value transparency. Liv Pure’s pricing tiers are clearly published, its per-bottle economics are favorable at the 6-bottle level, and the 60-day guarantee from ClickBank is identical to HepatoBurn’s. There is no pricing reason to choose HepatoBurn over Liv Pure.
HepatoBurn is not a bad product. Same vendor, same quality baseline, and a coherent thermogenic mechanism. But in a direct comparison, Liv Pure’s formula depth, ingredient transparency, and market credibility make it the default recommendation. If you are also curious whether Liv Pure might be overselling itself, our Liv Pure Scam or Legit? analysis addresses those concerns directly.
For additional context on how Liv Pure compares to other liver and metabolic supplements in the market, see our Ikaria Juice Review and Safe Natural Weight Loss Supplements overview. For a complete picture of who Sarah Reynolds is and her approach to supplement evaluation, visit our About page.
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11. Frequently Asked Questions
Is Liv Pure or HepatoBurn better for weight loss?
Liv Pure and HepatoBurn target liver health from different angles. Liv Pure emphasizes liver purification and detoxification (silymarin, glutathione, molybdenum, betaine) alongside fat-burning support. HepatoBurn leans more thermogenic, targeting liver fat burning more directly. For users with sluggish metabolism or mild liver burden concerns, Liv Pure’s purification approach may be a better fit. For users primarily seeking to accelerate fat burning from the liver side, HepatoBurn’s thermogenic focus may be more directly relevant. For the majority of users, Liv Pure’s broader mechanism is the stronger starting point.
Are Liv Pure and HepatoBurn made by the same company?
Yes — both Liv Pure and HepatoBurn are sold under the ClickBank vendor nickname “Jvwithae,” which operates multiple supplement brands. They are manufactured in FDA-registered, GMP-certified US facilities. Being same-vendor products does not mean identical formulas — the ingredient profiles differ meaningfully — but it does mean a similar quality and compliance baseline for manufacturing standards.
Which is cheaper, Liv Pure or HepatoBurn?
Liv Pure and HepatoBurn are priced in a similar range through ClickBank. Both offer multi-bottle discounts and 60-day money-back guarantees. Liv Pure’s best value is the 6-bottle package at approximately $39/bottle with free shipping, bringing the daily cost to about $2.60. See our Liv Pure Pricing page for current discount availability.
Can I take Liv Pure and HepatoBurn together?
We do not recommend combining Liv Pure and HepatoBurn. Both contain overlapping liver-support and metabolic ingredients, and doubling up without medical supervision could lead to excessive intake of certain compounds — for example, berberine at high cumulative doses significantly affects blood glucose and could interact with diabetes medications. Choose one product based on your primary goal and consult a healthcare provider before stacking supplements, particularly if you are on any chronic medications.
Which supplement has a better refund policy?
Both Liv Pure and HepatoBurn offer 60-day money-back guarantees processed through ClickBank. The refund mechanism is identical because they share the same payment processor. Either product can be returned within 60 days for a full refund regardless of how much you have used — no partial refund calculations, no usage conditions. This is one area where the two products are truly equal.
What makes Liv Pure different from HepatoBurn?
Liv Pure’s primary differentiator is its Liver Purification Complex — a blend of silymarin (milk thistle extract), glutathione, molybdenum, and betaine designed to address liver-level detoxification before optimizing fat metabolism. HepatoBurn focuses more directly on thermogenic liver fat burning, skipping the purification stage. A useful mental model: Liv Pure follows a “clean the engine, then optimize it” sequence, while HepatoBurn attempts to optimize the engine directly. For users dealing with dietary toxin burden, a history of processed food consumption, or regular alcohol intake, Liv Pure’s detox-first architecture is more mechanistically complete.
How long should I take Liv Pure before expecting results?
The Liv Pure manufacturer recommends a minimum of 30–90 days for meaningful results, and most customer reviews reporting visible changes reference 60–90 day timelines. This is consistent with the nature of liver-support interventions — liver enzyme normalization and hepatic fat reduction in clinical studies typically show measurable change over 8–12 weeks of consistent supplementation. We recommend the 3-bottle or 6-bottle package specifically because single-month trials are unlikely to be informative.
Is Liv Pure FDA approved?
No supplement is FDA approved in the way pharmaceuticals are. Liv Pure is manufactured in an FDA-registered facility operating under GMP (Good Manufacturing Practice) conditions, which means the production process meets federal standards for quality, cleanliness, and consistency. The product itself is not evaluated or approved by the FDA for any specific medical claim.
Ready to try the liver-focused formula with the stronger track record? Liv Pure’s 60-day guarantee means you can assess it risk-free for two full months. For best results, pair it with consistent hydration, reduced processed food intake, and moderate activity — the supplement supports the liver, but the lifestyle provides the foundation.
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These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.