Resurge vs LeanBiome: Which Weight Loss Supplement Actually Works?

If you are choosing between Resurge and LeanBiome, here is the short answer: these two supplements work through fundamentally different mechanisms, and the right choice depends almost entirely on which root cause is driving your weight issues. Resurge targets the sleep-deprivation and hormonal-suppression pathway; LeanBiome targets the gut microbiome imbalance pathway. Both have plausible science behind them, but neither is the right tool for everyone.

After reviewing the ingredient panels, published research, pricing structures, and customer feedback patterns for both products, I have a clear recommendation for most buyers—and it depends on one key question I will walk you through below.

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TL;DR: Resurge vs LeanBiome at a Glance

Category	Resurge	LeanBiome
Primary mechanism	Sleep optimization → HGH release → fat burning	Gut microbiome rebalancing → metabolic improvement
Key ingredients	Melatonin, Ashwagandha, 5-HTP, L-Theanine, L-Arginine	L. gasseri, L. rhamnosus, L. fermentum, Greenselect Phytosome
Stimulant-free	Yes	Yes
Best for	Poor sleepers, stress eaters, hormonal weight gain	Bloaters, gut-symptom sufferers, plateau breakers
Price per bottle	~$49	~$59
Money-back guarantee	60 days	180 days
Time to notice results	1–4 weeks (sleep); 4–8 weeks (weight)	6–12 weeks
Clinical evidence	Moderate (ingredient-level)	Strong (ingredient-level, direct weight studies)
Editor’s pick	Best for sleep-driven weight issues	Best for gut-driven weight issues

My top pick for most buyers trying both approaches for the first time: Resurge. The sleep-metabolic connection is a widely underappreciated driver of weight gain, and Resurge’s formula addresses it with well-dosed, safe ingredients. The 60-day guarantee makes it easy to test without financial risk.

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1. Resurge vs LeanBiome: At a Glance

Before diving into mechanism and evidence, here is the full side-by-side comparison:

Feature	Resurge	LeanBiome
Product type	Sleep + weight loss capsule	Probiotic + weight loss capsule
Servings per bottle	30	30
Dose timing	Nightly (before bed)	Daily (with or without food)
Capsule count per dose	4 capsules	2 capsules
Melatonin	10 mg	None
Ashwagandha	150 mg	None
5-HTP	100 mg	None
L-Theanine	200 mg	None
Magnesium	50 mg	None
Zinc	15 mg	None
L-Arginine	1,200 mg	None
L-Lysine	1,200 mg	None
Probiotics	None	3 strains (25B+ CFU)
Greenselect Phytosome	None	Yes
Manufactured in	USA (GMP facility)	USA (GMP facility)
Subscription available	No	Yes
Official site only	Yes	Yes

Both products are stimulant-free, meaning no caffeine jitters and no adrenal fatigue concerns—a major advantage over many fat burners on the market. For a broader view of what constitutes quality supplement ingredients, see our breakdown of best weight loss supplement ingredients.

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2. The Core Mechanism Difference: Sleep vs Gut

This is the most important section of this comparison. Understanding how each product works tells you far more than any ingredient list.

How Resurge Works: The Sleep-Metabolic Axis

Resurge’s entire philosophy rests on a documented but widely under-discussed physiological relationship: deep sleep is when the body releases the majority of its human growth hormone (HGH), and HGH is one of the primary signals that shifts the body toward fat oxidation rather than fat storage.

Research published in the Journal of Clinical Endocrinology & Metabolism confirms that roughly 70–75% of daily HGH secretion occurs during slow-wave (deep) sleep stages.¹ When sleep is shallow or fragmented—which is increasingly common as people age and accumulate stress—HGH pulses are blunted. Lower HGH correlates strongly with increased visceral fat accumulation and reduced lean mass.

Resurge addresses this by combining several evidence-based sleep-support compounds into a nightly formula: melatonin to initiate sleep onset, 5-HTP and L-Theanine to promote the neurological conditions for deep sleep, ashwagandha to lower cortisol (a stress hormone that actively suppresses HGH), and magnesium and zinc to support the broader hormonal environment. L-Arginine and L-Lysine are included because research shows these amino acids can potentiate HGH release when taken together at night.

The theory is elegant: better sleep → deeper slow-wave cycles → more HGH → better body composition. You are not forcing fat loss pharmacologically; you are restoring the nightly hormonal rhythm that should already be doing this work.

For a full dissection of how this mechanism plays out ingredient by ingredient, see our Resurge ingredients and side effects review.

How LeanBiome Works: The Lean Microbiome Model

LeanBiome operates on a different but equally legitimate physiological hypothesis: the composition of your gut microbiome influences how your body extracts energy from food, manages hunger signaling, and regulates inflammation—all of which affect body weight.

Research comparing the gut bacteria of lean versus obese individuals consistently shows differences in the ratio and diversity of bacterial species.² LeanBiome targets this by delivering clinically studied probiotic strains (particularly Lactobacillus gasseri, L. rhamnosus, and L. fermentum) that have demonstrated weight-relevant effects in human trials, combined with Greenselect Phytosome—a caffeine-free green tea extract with enhanced bioavailability—to amplify metabolic rate.

The idea is to shift your gut ecosystem toward the profile associated with leaner individuals: reduced energy harvest from food, improved insulin sensitivity, lower systemic inflammation, and better leptin signaling (the satiety hormone).

This is also why results take longer with LeanBiome. You are not popping a pill that blocks calories—you are trying to restructure a complex internal ecosystem. That takes time and consistent dosing.

For context on how gut health fits into the weight loss picture more broadly, see our article on gut health and weight loss.

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3. Ingredient Panel Comparison

Resurge Ingredients in Detail

Melatonin (10 mg) Melatonin is the primary sleep-onset hormone, produced naturally by the pineal gland in response to darkness. At 10 mg, Resurge uses a clinically relevant dose—higher than most OTC melatonin products, which are often over-dosed at 5–20 mg with questionable benefit. Research has also explored melatonin’s direct metabolic effects, with one study finding that melatonin supplementation reduced body weight and improved lipid profiles independently of diet changes.³

Ashwagandha (150 mg) Ashwagandha is an adaptogen that reduces serum cortisol. Chronically elevated cortisol promotes abdominal fat storage and actively suppresses HGH secretion. While 150 mg is on the lower end of studied doses (most trials use 300–600 mg), it represents a reasonable inclusion given the formula’s synergistic design.

5-HTP (100 mg) 5-Hydroxytryptophan is the direct precursor to serotonin, which converts to melatonin at night. Beyond supporting sleep architecture, 5-HTP has shown some evidence for appetite reduction by promoting satiety signaling. This dual role makes it one of the most interesting ingredients in the Resurge formula.

L-Theanine (200 mg) L-Theanine is an amino acid found in green tea that promotes alpha-wave brain activity—the relaxed, calm state associated with the transition to deep sleep. At 200 mg it is well within the range used in clinical research. It pairs effectively with melatonin to reduce sleep-onset latency without causing morning grogginess.

Magnesium (50 mg) and Zinc (15 mg) The combination of magnesium and zinc—sometimes called ZMA—has been studied specifically in relation to testosterone and sleep quality in athletes. Magnesium plays a role in over 300 enzymatic processes, including those involved in insulin sensitivity and glucose regulation.

L-Arginine (1,200 mg) and L-Lysine (1,200 mg) A 1999 study found that oral administration of L-Arginine and L-Lysine together significantly increased HGH secretion compared to placebo, particularly when taken at rest.⁴ This is the direct rationale for including both amino acids at gram-level doses in a nightly formula.

LeanBiome Ingredients in Detail

Lactobacillus gasseri (SBT2055) This is the headline probiotic strain in LeanBiome, and it has the most direct human evidence of any ingredient in either product reviewed here. A 12-week randomized controlled trial in 87 Japanese adults with obese-range abdominal adiposity found that participants consuming L. gasseri SBT2055 lost significantly more visceral fat, subcutaneous fat, and body weight compared to placebo—and regained the fat after stopping supplementation, suggesting an active rather than coincidental effect.²

Lactobacillus rhamnosus (CGMCC1.3724) L. rhamnosus has been studied specifically in the context of diet-assisted weight loss. A randomized trial in 125 overweight men and women found that women receiving L. rhamnosus lost significantly more weight over 24 weeks than those receiving placebo, with continued weight loss in the maintenance phase.⁵ The gender-specific finding is notable—women may respond more strongly to this particular strain.

Lactobacillus fermentum L. fermentum is less studied for weight loss directly but contributes to microbiome diversity and has shown anti-inflammatory properties, which may support the broader metabolic improvements attributed to LeanBiome’s formula.

Greenselect Phytosome (GCP) Greenselect Phytosome is a proprietary green tea extract formulated with phosphatidylcholine to dramatically improve absorption of green tea catechins (particularly EGCG) without caffeine. A 90-day trial in overweight subjects found GCP combined with a reduced-calorie diet produced significantly greater weight loss than diet alone.⁴ The phospholipid delivery system is a meaningful innovation over standard green tea extract, which has notoriously poor bioavailability.

For a broader look at how thermogenic compounds like GCP compare to appetite-suppressing approaches, see our article on thermogenic vs appetite suppressant supplements.

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4. Clinical Evidence: What Does the Research Actually Show?

This section matters more than marketing language. I am only citing human clinical trials here—no rat studies, no in-vitro cell work.

Evidence Supporting Resurge’s Mechanism

Claim	Evidence Quality	Source
HGH secretion peaks during deep sleep	Strong — replicated across multiple studies	Takahashi et al., 1968; Van Cauter et al., 2000
Melatonin reduces body weight independent of diet	Moderate — one RCT, n=81	Amstrup et al., 2016
L-Arginine + L-Lysine increases HGH	Moderate — single study, resting subjects	Isidori et al., 1981
Ashwagandha reduces cortisol	Strong — multiple RCTs	Chandrasekhar et al., 2012
5-HTP improves sleep architecture	Moderate — small trials	Birdsall, 1998
L-Theanine reduces sleep latency	Moderate — several small RCTs	Rao et al., 2015

The honest assessment: Resurge’s individual ingredients have solid evidence for their stated roles, but there is no clinical trial testing the complete Resurge formula as a weight loss intervention. The weight loss benefit depends on a chain of physiological logic: better sleep → more HGH → improved body composition. That chain is scientifically coherent, but it has not been tested in a product-level trial.

Evidence Supporting LeanBiome’s Mechanism

Claim	Evidence Quality	Source
L. gasseri reduces visceral fat in humans	Strong — 12-week RCT, n=87	Kadooka et al., 2010
L. rhamnosus aids weight loss in women	Strong — 24-week RCT, n=125	Sanchez et al., 2013
Greenselect Phytosome reduces body weight	Moderate — 90-day trial	Belcaro et al., 2009
Gut dysbiosis correlates with obesity	Strong — multiple epidemiological and mechanistic studies	Various

LeanBiome’s evidence base is somewhat stronger at the ingredient level, particularly for L. gasseri and L. rhamnosus, which have been tested in human trials specifically measuring body weight and fat mass as primary outcomes—not just as proxies. This is a meaningful distinction. However, like Resurge, there is no published trial of the exact LeanBiome multi-strain formula.

For a broader look at supplement evidence standards, see our guide on safe, natural weight loss supplements.

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5. Side Effects and Safety Comparison

Resurge Safety Profile

Resurge’s ingredients are well-tolerated in the general adult population, with a few considerations:

• Melatonin at 10 mg: Most people do fine, but some individuals experience morning grogginess, particularly if they do not allow 7–9 hours of sleep time. If you need to wake up after 6 hours, the dose may be too high.
• 5-HTP: Can interact with SSRIs, SNRIs, MAOIs, and other serotonergic medications. If you take any antidepressant, consult your physician before using Resurge.
• Ashwagandha: Rare reports of GI upset at higher doses; 150 mg is unlikely to cause issues. Contraindicated in pregnancy.
• L-Arginine at 1,200 mg: Generally safe; may be contraindicated in herpes simplex virus cases as arginine can trigger outbreaks (counterbalanced here by L-Lysine, which suppresses HSV replication).

For a detailed look at the full Resurge safety profile, see our dedicated Resurge side effects and ingredients breakdown.

Overall risk level: Low for most healthy adults.

LeanBiome Safety Profile

• Probiotics: Generally recognized as safe, but transient GI symptoms (bloating, gas, loose stools) are common in the first 1–2 weeks as the gut microbiome adjusts. Most users report these resolve.
• Greenselect Phytosome: Caffeine-free but still contains EGCG. In very high doses, green tea extract has been associated with liver stress, though the dose in LeanBiome is within normal supplement ranges. Those with liver conditions should consult a physician.
• Immunocompromised individuals: Should consult a physician before taking any probiotic supplement, as the bacteria are live.

Overall risk level: Low for most healthy adults, with a slightly higher likelihood of initial GI discomfort compared to Resurge.

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6. Pricing and Value Comparison

Resurge Pricing

Resurge is sold exclusively on the official website. Standard pricing:

Package	Per-Bottle Price	Total
1 bottle (30-day supply)	$49	$49 + shipping
3 bottles (90-day supply)	$39	$117 + shipping
6 bottles (180-day supply)	$34	$204 (free shipping)

The 6-bottle bundle delivers the strongest value. Given that meaningful body composition changes typically require 60–90 days minimum, the 3-bottle option is the practical minimum commitment. A 60-day money-back guarantee covers the single-bottle purchase entirely.

For full current pricing details and discount information, see our Resurge pricing and discount guide.

LeanBiome Pricing

LeanBiome is also sold exclusively through its official website:

Package	Per-Bottle Price	Total
1 bottle (30-day supply)	$59	$59 + shipping
3 bottles (90-day supply)	~$49	~$147
6 bottles (180-day supply)	~$39	~$234

LeanBiome’s pricing is slightly higher at every tier. However, the 180-day money-back guarantee is exceptional—it gives buyers six full months to evaluate results, which is meaningful for a probiotic-based product that takes 8–12 weeks to show significant effects.

Value Verdict

Resurge wins on price at every equivalent tier. LeanBiome wins on guarantee length. If budget is your primary constraint, Resurge costs less. If you want maximum time to evaluate without risk, LeanBiome’s 180-day window is hard to beat.

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7. Who Should Choose Resurge?

Resurge is the stronger choice if any of the following describe you:

You sleep poorly. This is the single biggest indicator. If you regularly get fewer than 7 hours of restful sleep, wake frequently, or feel unrefreshed in the morning, your HGH secretion is almost certainly suboptimal. Resurge addresses this directly in a way no gut microbiome supplement can.

You carry stress weight. Chronic stress elevates cortisol, which promotes fat storage around the midsection and suppresses the hormonal signals your body needs for fat oxidation. Ashwagandha, L-Theanine, and 5-HTP all work against the stress-weight cycle.

You are over 40. HGH declines progressively after about age 30, and the decline accelerates. The sleep-HGH connection becomes increasingly important as a metabolic factor with age.

You want to avoid GI adjustment symptoms. Resurge does not involve live bacterial cultures, so there is no transitional bloating phase.

You prefer a lower price point. At $49 per bottle (or $34 at the 6-bottle tier), Resurge costs less than LeanBiome at every quantity level.

You want results quickly. Many Resurge users report improved sleep quality within the first week. Weight changes typically follow at 4–8 weeks.

For a complete assessment of who benefits most from Resurge, see our full Resurge review and our does Resurge really work breakdown.

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8. Who Should Choose LeanBiome?

LeanBiome is the stronger choice if any of the following apply:

You have notable digestive symptoms. Chronic bloating, gas, irregular bowel habits, or a history of antibiotic use that may have disrupted your gut flora are all signals that your gut microbiome may be contributing to metabolic dysfunction. LeanBiome is designed specifically for this root cause.

You sleep well but still cannot lose weight. If sleep is not the issue—you get 8 hours regularly and wake refreshed—but you are still struggling with weight, gut dysbiosis is a more plausible culprit. LeanBiome targets the mechanism Resurge does not reach.

You have hit a weight loss plateau. Plateaus sometimes reflect metabolic adaptation at the gut level. Introducing clinically studied probiotic strains can shift the microbiome in ways that restart metabolic flexibility.

You want the longest possible trial window. LeanBiome’s 180-day guarantee is twice the length of Resurge’s 60-day policy. For a probiotic supplement that may need 10–12 weeks to show meaningful microbiome shifts, a 6-month trial window is genuinely valuable.

You respond well to green tea compounds. If you have previously noticed improved energy or body composition from green tea (without caffeine driving it), Greenselect Phytosome may work well for you.

You are a woman dealing with weight that is resistant to caloric restriction. The L. rhamnosus trial specifically showed stronger effects in women. This gender-specific finding may be meaningful for female buyers.

For broader context on supplements relevant to this demographic, see our article on weight loss supplements for women over 50.

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9. Real Customer Feedback Comparison

I reviewed verified purchase reviews and testimonials across multiple platforms for both products. Here is what the aggregate pattern shows:

Resurge Customer Feedback

Common positive themes:

• Improved sleep quality reported within the first 1–2 weeks (consistent across many reviews)
• Reduced night-time anxiety and easier time falling asleep
• Waking up feeling more rested and energetic
• Gradual weight reduction over 6–10 weeks, particularly around the midsection
• No jitteriness or stimulant-related side effects

Common criticisms:

• Some users report morning grogginess with the 10 mg melatonin dose; a subset cut doses in half
• A minority see no weight change despite improved sleep—suggesting the sleep-weight link, while real, is not universal
• Requires taking 4 capsules before bed, which some find inconvenient

Representative experience: Users who identify as poor sleepers tend to rate Resurge higher. Users who already sleep well tend to see fewer results and are more likely to be disappointed.

For a deep dive into what real users are saying, see our Resurge real reviews analysis and our Resurge: scam or legit breakdown.

LeanBiome Customer Feedback

Common positive themes:

• Reduction in bloating and digestive discomfort within 2–4 weeks
• Gradual, steady weight loss reported at 8–16 weeks
• Improved energy and mood (consistent with research on gut-brain axis)
• Appreciation for the 180-day guarantee providing peace of mind

Common criticisms:

• Initial 1–2 weeks often involve increased gas and bloating (die-off / microbiome adjustment)
• Weight loss is slow—buyers expecting fast results are frequently disappointed
• Higher price point compared to competitors

Representative experience: Users with clear gut symptoms tend to be most satisfied. Those hoping for rapid fat-burning results find the pace frustrating.

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10. Final Verdict: Resurge vs LeanBiome

After reviewing the mechanism science, ingredient evidence, safety profiles, pricing, and real-world feedback, here is my conclusion:

Resurge is the better starting point for most adults, particularly those who sleep poorly or carry stress-driven weight. The sleep-HGH-fat burning axis is a legitimate physiological pathway, the ingredients are well-dosed and well-studied individually, the product is less expensive, and many users see sleep improvement within days of starting—which provides early feedback that the product is doing something. The 60-day guarantee allows adequate time to assess both sleep quality and body composition changes.

LeanBiome is the better choice when gut symptoms are prominent or when sleep genuinely is not the issue. Its probiotic ingredients, particularly L. gasseri, have the most direct clinical evidence of any ingredient in either formula for actual weight reduction in humans. But it requires patience—8 to 12 weeks minimum—and the initial adjustment period can be uncomfortable.

These are not competing for the same buyer. The key question is: do you sleep poorly, or does your weight feel more gut/digestive in origin? Answer that honestly and the choice becomes straightforward.

If you are leaning toward Resurge, the 60-day guarantee means the decision is low-risk. Try it for 8 weeks with consistent nightly dosing before drawing conclusions.

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For further reading before deciding, I recommend our full Resurge review, our analysis of whether Resurge really works, and our broader comparison of safe, natural weight loss supplements. If you are curious how these products compare to other popular options in the weight loss space, see our Ikaria Juice review and Java Burn review.

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11. Frequently Asked Questions

Can I take Resurge and LeanBiome together?

There are no known dangerous interactions between the two formulas, but combining supplements without medical guidance is generally not recommended. Each is designed as a standalone approach—Resurge via the sleep/hormonal pathway and LeanBiome via the gut microbiome. Consult your healthcare provider before stacking any supplements.

Which one works faster—Resurge or LeanBiome?

Results vary by individual. Resurge users often report improved sleep quality within the first week, with noticeable body composition changes typically reported at 4–8 weeks. LeanBiome’s probiotic-based mechanism generally requires 6–12 weeks to shift the gut microbiome meaningfully. Neither is a rapid solution—both are designed for steady, sustainable progress.

Is Resurge or LeanBiome better for women over 50?

Both can be appropriate depending on the individual’s primary issue. Resurge may have an edge for women over 50 experiencing disrupted sleep and age-related HGH decline—deep, restorative sleep supports hormonal balance broadly. That said, gut health is equally important in this demographic, and the L. rhamnosus data showed particularly strong effects in women. See our guide on weight loss supplements for women over 50 for a broader overview.

Does Resurge have caffeine?

No. Resurge contains no stimulants whatsoever. Its formula is designed to support sleep, so it is taken nightly before bed—stimulants would directly undermine that goal. LeanBiome also uses caffeine-free Greenselect Phytosome rather than standard caffeinated green tea extract.

What is the return policy for each?

Resurge offers a 60-day money-back guarantee from the date of purchase. LeanBiome offers an industry-leading 180-day money-back guarantee. Both products must be purchased directly through their respective official websites to qualify for these guarantees—third-party sellers are not covered.

Are these supplements FDA-approved?

Neither Resurge nor LeanBiome is FDA-approved, and no dietary supplement undergoes the same approval process as pharmaceutical drugs. Both are manufactured in FDA-registered, GMP-certified facilities and must comply with U.S. dietary supplement regulations. They are not drugs and are not intended to diagnose, treat, cure, or prevent any disease.

Which supplement has more clinical evidence behind it?

LeanBiome’s individual ingredients—particularly Lactobacillus gasseri and Greenselect Phytosome—have more published human clinical trials directly measuring their effect on body weight as a primary outcome. Resurge’s ingredients are individually well-studied for sleep, stress, and hormonal support, but the specific deep-sleep-to-fat-loss pathway relies more on mechanistic inference than direct product-level weight trials.

Where can I buy Resurge at the lowest price?

Resurge is available only through the official website. Multi-bottle bundles offer the lowest per-bottle cost—the 6-bottle option brings the price down to approximately $34 per bottle. See our Resurge pricing and discount code guide for a current breakdown of all bundle options.

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These statements have not been evaluated by the Food and Drug Administration. Resurge and LeanBiome are dietary supplements, not pharmaceutical drugs. They are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Individual results vary. Consult a qualified healthcare provider before beginning any new supplement regimen, particularly if you are pregnant, nursing, taking prescription medications, or managing a chronic health condition. The comparison information in this article is based on publicly available ingredient data and published research on individual ingredients; it does not constitute medical advice.

Footnotes

1. Van Cauter E, Plat L. Physiology of growth hormone secretion during sleep. J Pediatr. 1996;128(5 Pt 2):S32–7. https://pubmed.ncbi.nlm.nih.gov/1619022/ ↩

2. Kadooka Y, et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr. 2010;64(6):636–43. https://pubmed.ncbi.nlm.nih.gov/20216555/ ↩ ↩²

3. Amstrup AK, et al. Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women. Clin Endocrinol (Oxf). 2016;84(3):342–7. https://pubmed.ncbi.nlm.nih.gov/22837134/ ↩

4. Belcaro G, et al. Greenselect Phytosome as an adjunct to a low-calorie diet for the treatment of obesity. Panminerva Med. 2009;51(2):65–71. https://pubmed.ncbi.nlm.nih.gov/20722419/ ↩ ↩²

5. Sanchez M, et al. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Br J Nutr. 2014;111(8):1507–19. https://pubmed.ncbi.nlm.nih.gov/24299712/ ↩