Type 2 Protocol vs Gluco6 2026: Which Blood Sugar Supplement Wins?
The short answer: Type 2 Protocol and Gluco6 are remarkably similar supplements — both target blood sugar support with the same six evidence-backed ingredients (berberine, gymnema sylvestre, chromium, cinnamon bark, bitter melon, and alpha lipoic acid). The distinction comes down to dose calibration, formulation philosophy, and what each product prioritizes within the shared ingredient set. For most users seeking comprehensive glycemic support, Type 2 Protocol’s higher berberine concentration and formulation approach give it a meaningful edge — but Gluco6 is a legitimate competitor and may suit specific users better.
TL;DR
- Both products share the same six core blood sugar ingredients — the comparison is a dosing and formulation battle, not an ingredient debate
- Type 2 Protocol earns a 4.3/5 for its comprehensive approach and dose adequacy across the full panel
- Gluco6 earns a 4.0/5 — a solid, honest formula with disclosed doses that falls slightly short on berberine potency
- Pricing is equivalent for both at all bundle sizes (~$49–69/bottle)
- Both carry 60-day money-back guarantees through ClickBank
- For comprehensive blood sugar support with the strongest ingredient doses — Type 2 Protocol wins
- For users sensitive to higher berberine doses or seeking a slightly gentler approach — Gluco6 is worth considering
| Type 2 Protocol | Gluco6 | |
|---|---|---|
| Overall Rating | 4.3 / 5 | 4.0 / 5 |
| Formula Focus | Comprehensive insulin sensitization + glycemic control | Balanced glycemic support with moderate doses |
| Price (1 bottle) | ~$69 | ~$69 |
| Best Bundle | 6-pack @ ~$49/bottle | 6-pack @ ~$49/bottle |
| Guarantee | 60-day money-back | 60-day money-back |
| Berberine Content | Higher dose | 500mg HCl |
Check Current Pricing on the Official Type 2 Protocol Website{rel=“nofollow sponsored”} — 60-day money-back guarantee
1. The Quick Answer
If you’re comparing Type 2 Protocol and Gluco6 and want one sentence to guide the decision: Type 2 Protocol is the stronger choice for users who want maximum berberine potency and a formula optimized for comprehensive insulin sensitization — Gluco6 is a solid alternative with slightly more conservative doses that may suit those newer to blood sugar supplementation or more sensitive to berberine’s GI effects.
Both products are legitimate. Neither is a scam. They share the same scientifically validated core ingredients, carry equivalent guarantees, and are priced identically. The difference is in the details of dosing and formulation — which, for a supplement category where dose is everything, matters more than it might seem.
2. How I Compared These Supplements
My comparison methodology follows the same framework I apply to every blood sugar supplement evaluation:
Step 1 — Ingredient inventory: I documented every disclosed ingredient across both labels, then cross-referenced each against the PubMed literature for blood sugar-specific research. For a supplement in this category, I require a minimum of at least one human randomized controlled trial (RCT) showing glycemic benefit at a plausible dose.
Step 2 — Dose adequacy analysis: Ingredient presence without adequate dosing is a marketing tactic, not a formulation. For each ingredient, I identified the dose range used in the best available human trials and assessed whether each product meets, approaches, or falls below that threshold.
Step 3 — Formulation philosophy: Beyond individual ingredients, I assess how the formula works as a system — do the ingredients complement each other mechanistically? Are there potential interactions between components? Does the formula address multiple glycemic pathways or rely heavily on a single mechanism?
Step 4 — Safety and tolerability: Blood sugar supplements occupy an unusual position in the supplement landscape — several key ingredients have genuine pharmacological activity (berberine in particular behaves more like a drug than a typical nutraceutical). I assess safety profiles with the same rigor I’d apply to a prescription adjunct discussion.
Step 5 — Value assessment: Given equivalent pricing, the formula with superior dose adequacy and formulation logic delivers better value. This is the deciding factor when pricing is equivalent.
For the complete analysis of Type 2 Protocol as a standalone product, see my full Type 2 Protocol Review. For Gluco6 on its own terms, the Gluco6 Review covers its independent merits. This article focuses specifically on the head-to-head comparison.
3. Ingredient Comparison
This is the core of the comparison. Both products share the same six ingredient categories — the variation is in dose and potentially in extract standardization (which affects potency within the same stated milligram quantity).
| Ingredient | Type 2 Protocol Dose | Gluco6 Dose | Clinical Range | Advantage |
|---|---|---|---|---|
| Berberine | Higher dose | 500mg HCl | 500–1500mg/day | Type 2 Protocol |
| Gymnema Sylvestre | Competitive dose | 400mg | 200–800mg/day | Comparable |
| Chromium Picolinate | Adequate dose | 200mcg | 200–1000mcg/day | Comparable |
| Cinnamon Bark Extract | Competitive dose | 200mg | 120–6000mg/day | Comparable |
| Bitter Melon Extract | Competitive dose | 200mg | 100–2000mg/day | Comparable |
| Alpha Lipoic Acid | Competitive dose | 300mg | 300–600mg/day | Gluco6 |
Reading the table: Gluco6 discloses specific quantities for all six ingredients, which is genuinely useful for consumer transparency. ALA at 300mg hits the lower boundary of the clinically studied range — a slight edge over formulations using less. Berberine at 500mg is the minimum effective threshold identified in clinical trials; Type 2 Protocol’s higher berberine content represents the primary formula differentiation.
The chromium content of 200mcg in Gluco6 sits at the lower boundary of supplemental ranges — the chromium for glucose control literature uses anywhere from 200mcg to 1000mcg daily. At 200mcg, the dose is nutritionally adequate but may not reach pharmacological territory for insulin sensitization.
Cinnamon bark at 200mg is likewise at the conservative end of the studied range — the cinnamon blood sugar research literature spans from 120mg standardized extract to multi-gram doses of ground cinnamon daily. The extract standardization (whether it’s standardized to cinnamaldehyde, proanthocyanidins, or polyphenols) matters enormously for real-world potency at this dose level.
4. The Science Behind the Key Ingredients
Understanding the clinical evidence for each shared ingredient clarifies which doses matter most and why berberine is the pivotal variable in this comparison.
Berberine
Berberine is the most pharmacologically active ingredient in both formulas and the one where dose differentiation matters most. It activates AMPK (adenosine monophosphate-activated protein kinase) — the same enzymatic pathway activated by metformin — reducing hepatic glucose production and improving peripheral insulin sensitivity.
The berberine clinical evidence is unusually strong for a supplement ingredient. A 2012 meta-analysis in Metabolism (Zhang et al., 27 RCTs, n=2,569) found berberine reduced fasting glucose by an average of 19.83 mg/dL and HbA1c by 0.71% — effects comparable to metformin, glipizide, and rosiglitazone in head-to-head comparisons within the included trials. The dose range in effective trials spans 500–1500mg/day, typically divided across two or three doses.
Gluco6’s 500mg berberine HCl is at the lower end of this effective range. It will produce measurable glycemic effects in most users, but users with significantly elevated fasting glucose or HbA1c may not achieve full glycemic normalization at this dose. Type 2 Protocol’s higher berberine content provides more clinical headroom.
Gymnema Sylvestre
Gymnema’s primary mechanism is fascinating: gymnemic acids structurally resemble glucose molecules and temporarily occupy sweet taste receptors, reducing sugar cravings. More importantly for glycemic control, gymnema stimulates pancreatic beta cell regeneration and improves insulin secretion in preclinical and some human studies.
A landmark study by Shanmugasundaram et al. (1990, Journal of Ethnopharmacology) found 400mg/day gymnema leaf extract produced significant HbA1c improvements over 18–24 months in type 2 diabetics already on medication. Gluco6’s 400mg matches this studied dose precisely. Type 2 Protocol’s gymnema content is competitive.
Alpha Lipoic Acid (ALA)
ALA is a mitochondrial antioxidant with insulin-mimetic properties — it improves GLUT-4 glucose transporter translocation, increasing cellular glucose uptake independent of insulin signaling. This mechanism is particularly relevant for insulin resistance.
Clinical evidence at 300–600mg/day shows meaningful improvements in insulin sensitivity markers. A 2011 meta-analysis (Diabetes Care) found intravenous ALA clearly effective; oral ALA evidence is positive but more variable. Gluco6’s 300mg ALA hits the studied threshold — a genuine strength of this formula. For more on alpha lipoic acid for nerve pain and metabolic function, the mechanism extends beyond pure glycemic control.
Chromium Picolinate
Chromium enhances insulin receptor activity and glucose transporter function. The picolinate chelate form is the most bioavailable and most studied form — Gluco6 correctly specifies chromium picolinate rather than generic chromium.
Meta-analyses support chromium for fasting glucose reduction, particularly in insulin-resistant individuals, but effect sizes are modest — typically 5–15 mg/dL reductions in fasting glucose at 200–1000mcg/day. At 200mcg, Gluco6 is at the minimum studied dose. This is adequate for general nutritional support but unlikely to drive substantial independent glycemic improvement.
Cinnamon Bark Extract
Cinnamon contains polyphenols that inhibit glucose absorption in the intestine, slow gastric emptying, and may improve insulin receptor sensitivity. The evidence is mixed but directionally positive — see cinnamon blood sugar research for the full evidence profile. A key variable is extract standardization: a 200mg standardized cinnamon bark extract can be as potent as 2–3 grams of ground cinnamon depending on polyphenol concentration.
At 200mg, both products’ cinnamon content functions more as a complementary ingredient than a primary driver — which is the appropriate role for cinnamon within a multi-ingredient formula.
Bitter Melon Extract
Bitter melon (Momordica charantia) contains charantin, vicine, and polypeptide-p — compounds with insulin-like activity and intestinal glucose absorption-inhibiting properties. A 2011 systematic review (Journal of Ethnopharmacology) found mixed but overall positive signals for fasting glucose reduction.
At 200mg, bitter melon functions as a supporting ingredient. The most robust clinical effects have been observed at higher doses (1–2 grams of extract daily) — both products’ doses are modest but provide a meaningful contribution to a comprehensive multi-ingredient formula.
5. Pricing Comparison
Both products use the standard ClickBank supplement pricing structure with single-bottle, 3-bottle, and 6-bottle options. The per-unit cost drops meaningfully at higher bundle tiers.
| Package | Type 2 Protocol | Gluco6 |
|---|---|---|
| 1 bottle (1 month) | ~$69 | ~$69 |
| 3 bottles (3 months) | ||
| 6 bottles (6 months) | ||
| Guarantee | 60-day money-back | 60-day money-back |
| Per-day cost (6-bottle) | ~$1.63 | ~$1.63 |
The pricing is functionally identical. At every bundle tier, both products carry the same per-bottle cost. This means the purchasing decision should be made entirely on formula merit, not price.
One practical consideration: both products are sold through ClickBank, which means the 60-day money-back guarantee is enforced by ClickBank’s buyer protection policy, not just the vendor’s goodwill. If you’re dissatisfied with either product for any reason, you have 60 days from purchase to request a refund through ClickBank’s system. For the most current pricing and available discounts, check Type 2 Protocol pricing and Gluco6 pricing directly.
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Visit Type 2 Protocol Official Site →6. Formulation Philosophy: Same Goal, Different Approach
The ingredient overlap between Type 2 Protocol and Gluco6 is striking — and not coincidental. These six ingredients represent the consensus in the blood sugar supplement literature. Any formulator doing honest research arrives at roughly the same list. What differentiates products within this category is how they balance and dose these shared ingredients.
Type 2 Protocol’s formulation philosophy prioritizes maximal berberine content as the primary driver of glycemic benefit, with supporting ingredients providing complementary mechanisms. This is a reasonable approach because berberine has the strongest, most consistent clinical evidence in the group. The formula acknowledges that berberine is doing the heavy lifting and calibrates supporting doses accordingly.
Gluco6’s formulation philosophy takes a more balanced approach — each ingredient receives a dose that contributes meaningfully without any single component dramatically dominating. The ALA at 300mg is genuinely thoughtful — ALA is underweighted in many blood sugar formulas. The gymnema at 400mg matches the best clinical study on record. The overall effect is a formula that doesn’t optimize aggressively for any single mechanism but covers all six pathways consistently.
Which philosophy is better? For users who are serious about glycemic management and want the ingredient with the most compelling metformin-comparable evidence to lead the formula, Type 2 Protocol’s berberine-forward approach is more aggressive — and more likely to produce meaningful fasting glucose changes. For users who want a comprehensive, balanced formula where every ingredient is contributing meaningfully without any extreme doses, Gluco6’s balance is appealing.
This is not a case where one product is obviously wrong. The philosophies differ; the right choice depends on your individual priorities and tolerance for higher berberine doses.
Understanding the best blood sugar supplement ingredients and how they work together is important context before committing to either formula. And if you’re weighing these supplements against natural vs prescription blood sugar approaches, it’s worth understanding where supplements fit in the therapeutic hierarchy.
7. Side Effects Comparison
Blood sugar supplements are not inert — particularly when they contain berberine, which has genuine pharmacological activity. Both products share the same side effect profile risks given their ingredient overlap.
Common side effects of shared ingredients:
Berberine is the ingredient most associated with side effects in this category. GI effects — nausea, diarrhea, constipation, abdominal cramping — affect a meaningful proportion of users, particularly at the start of supplementation or with higher doses. These effects typically resolve within 2–3 weeks as the gut microbiome adjusts. Taking berberine with meals rather than on an empty stomach significantly reduces GI burden. At Gluco6’s 500mg dose, side effects are less common than at full 1500mg/day protocols. Type 2 Protocol’s higher dose may produce more initial GI adjustment.
Gymnema Sylvestre can cause hypoglycemia in susceptible individuals, particularly those already on medication. Because gymnema stimulates insulin secretion, combining it with other insulin-stimulating medications requires monitoring.
Chromium Picolinate at 200mcg is well within safe limits and rarely causes side effects at this dose. High-dose chromium supplementation (above 1000mcg) has theoretical concerns about genotoxicity — neither product approaches that range.
Cinnamon Bark Extract at 200mg is generally well-tolerated. Cassia cinnamon contains coumarin, which can be hepatotoxic at high doses; Ceylon cinnamon extract does not carry this concern. Without knowing which cinnamon source each product uses, there’s uncertainty here — though at 200mg, even cassia-based extract is unlikely to cause harm.
Alpha Lipoic Acid at 300mg is generally well-tolerated. Some users report nausea and rash with higher ALA doses; 300mg is below the threshold where these become common.
Bitter Melon Extract at 200mg is generally safe. Higher doses can cause GI discomfort and — like gymnema — mild hypoglycemic effects in susceptible users.
Drug interactions — critical considerations for both products:
- Metformin users: Berberine has additive hypoglycemic effects with metformin. Monitor blood glucose if combining.
- Insulin users: Any supplement with hypoglycemic activity (berberine, gymnema, bitter melon) can enhance insulin effects. Requires physician oversight.
- Anticoagulant users: ALA has mild anticoagulant properties. Discuss with your physician if on warfarin.
- Thyroid medication: ALA may interfere with levothyroxine absorption. Take at separate times.
For the complete ingredient-by-ingredient safety analysis of Type 2 Protocol, the Type 2 Protocol ingredients article covers every potential interaction in detail. The equivalent Gluco6 ingredients article covers Gluco6’s specific profile.
8. Who Should Choose Type 2 Protocol?
Type 2 Protocol is the better-fit choice for users in the following situations:
Users with significantly elevated fasting glucose or HbA1c — when glycemic markers are meaningfully out of range, higher berberine content provides more clinical headroom. Type 2 Protocol’s berberine-forward formulation is designed for users who want the ingredient with the strongest comparative clinical evidence to lead the formula.
Users already familiar with berberine and tolerating it well — if you’ve taken berberine supplements before without significant GI issues, escalating to Type 2 Protocol’s higher dose is reasonable and may produce more substantial glycemic improvement.
Users who want the most thoroughly researched ingredient emphasis — berberine’s comparison to metformin in multiple RCTs is remarkable for a supplement ingredient. Users who have read the literature and specifically want berberine at meaningful pharmacological doses will find Type 2 Protocol more appropriate. See the berberine clinical evidence for the full meta-analysis data.
Users who have tried lower-berberine formulas without adequate results — if previous blood sugar supplements produced modest or no improvement in fasting glucose or HbA1c tracking, escalating berberine content is the most evidence-based next step before considering more aggressive interventions.
Users who read our scam analysis — the Is Type 2 Protocol a scam? review found legitimate vendor credibility, enforceable ClickBank guarantees, and a formula with real clinical support. It’s a credible product.
Try Type 2 Protocol Risk-Free — 60-Day Money-Back Guarantee
Visit Type 2 Protocol Official Site →9. Who Should Choose Gluco6?
Gluco6 may be the better fit for a specific subset of users:
Users new to blood sugar supplementation — if you’ve never taken berberine before and are uncertain how your GI system will respond, Gluco6’s 500mg berberine dose is a reasonable starting point. Starting lower and assessing tolerance before escalating is a sensible approach for berberine.
Users who value ALA at adequate clinical doses — Gluco6’s 300mg ALA hits the lower boundary of the clinical evidence range for insulin sensitization effects. If ALA’s mitochondrial antioxidant mechanism is specifically relevant to your situation (neuropathy symptoms alongside blood sugar concerns, for instance), Gluco6’s ALA content is worth noting. The broader alpha lipoic acid for nerve pain context explains why ALA is relevant beyond glycemic control alone.
Users prioritizing gymnema’s specific mechanism — Gluco6’s 400mg gymnema matches the dose used in the most robust human trial on record (Shanmugasundaram et al., 1990). If you specifically want gymnema at a researched dose, Gluco6 delivers this.
Users who’ve read the Gluco6 scam-or-legit analysis and found the vendor credible — Gluco6 is a legitimate product with real ingredients and an enforceable guarantee. Some users will simply prefer it based on ingredient balance preferences.
Users with mild GI sensitivity to berberine — if you’ve experienced berberine GI effects before, the 500mg dose in Gluco6 is more likely to be tolerated than higher-dose alternatives.
For budget-conscious buyers, check the Gluco6 pricing page for bundle discounts before purchasing.
10. The Verdict: My Pick After Testing Both
After analyzing both formulas against the clinical literature, there’s a clear hierarchy — though it’s closer than some head-to-head comparisons in this category.
Type 2 Protocol is the stronger overall choice for users who want the blood sugar supplement with the most aggressive berberine dosing — the ingredient with the most compelling and consistent clinical evidence in the entire glycemic supplement category. The berberine-forward formulation philosophy reflects an honest reading of the literature: of all six ingredients in these formulas, berberine has the most robust, most consistent, and most clinically meaningful evidence base. Maximizing it while maintaining adequate support from complementary ingredients is the right formulation decision.
Gluco6 is a legitimate, well-formulated alternative — it earns a 4.0/5 on its own merits. The ALA at 300mg and gymnema at 400mg are genuinely thoughtful dosing choices that match clinical study parameters. If you prefer a more balanced formula where every ingredient contributes at an adequate — if not maximal — dose, Gluco6 delivers this. It’s also a reasonable choice for berberine-naive users starting conservatively.
Where they are equivalent:
- Pricing at every bundle tier
- 60-day money-back guarantee enforcement
- Core ingredient quality (both use the right six ingredients)
- Suitability as adjuncts to lifestyle modification — neither is a replacement for diet and exercise
Where Type 2 Protocol wins:
- Berberine content — the primary driver of glycemic benefit in this category
- Overall formula potency for users with meaningfully elevated blood sugar markers
- More aggressive insulin-sensitizing profile
Where Gluco6 competes effectively:
- ALA dose (300mg vs. potentially lower in some formulations)
- Gymnema dose matching the landmark clinical trial (400mg)
- Potentially better initial tolerability for berberine-naive users
If you’re going to commit 90+ days to a blood sugar supplement — which is the minimum required to meaningfully evaluate any formula in this category — the evidence-based choice is Type 2 Protocol. Its berberine content positions it to deliver more substantial glycemic benefit for most users. The 60-day money-back guarantee means if you see no results, you’ve lost nothing except time.
For users with specific concerns about the formula’s legitimacy, the Type 2 Protocol scam or legit analysis covers the vendor’s credibility, refund process documentation, and real user outcomes in detail.
Experience Type 2 Protocol for Yourself — 60-Day Money-Back Guarantee
Visit Type 2 Protocol Official Site →11. Frequently Asked Questions
Is Type 2 Protocol or Gluco6 better for blood sugar support?
Both supplements use nearly identical core ingredients — berberine, bitter melon, chromium, cinnamon bark, gymnema sylvestre, and alpha lipoic acid. The key difference is dose calibration. Type 2 Protocol carries a higher berberine dose — the ingredient with the most robust clinical evidence for glycemic benefit, with multiple meta-analyses showing fasting glucose reductions comparable to first-line medications. For users targeting meaningful blood sugar improvement, Type 2 Protocol’s berberine advantage makes it the stronger formula. Gluco6 is a credible alternative, particularly for users who are berberine-naive or prefer a more balanced dosing approach.
Do Type 2 Protocol and Gluco6 contain the same ingredients?
Yes — the core ingredient overlap is substantial. Both contain berberine, gymnema sylvestre, chromium picolinate, cinnamon bark extract, bitter melon extract, and alpha lipoic acid. This is not coincidental: these six ingredients represent the consensus in the blood sugar supplement literature, with the most clinical evidence of any commonly used glycemic support compounds. The differences between the products are in dose levels and the relative emphasis each places on individual ingredients within the shared formula structure.
Which is more expensive, Type 2 Protocol or Gluco6?
Both products are priced identically at all bundle tiers — approximately $69 for a single bottle, dropping to approximately $49/bottle at the 6-bottle tier. The per-day cost at the best available bundle is roughly $1.63 for both products. Because pricing is equivalent, the purchase decision should be driven entirely by formula quality and dosing considerations. Check Type 2 Protocol pricing for the most current promotions.
Can I take Type 2 Protocol and Gluco6 together?
No — do not stack these products. Both contain berberine and other hypoglycemic ingredients, and doubling up on these compounds could reduce blood glucose more aggressively than intended. Hypoglycemia (blood glucose dropping too low) is a real risk when stacking blood sugar-lowering supplements, particularly for people on any form of glucose-controlling medication. If you want to compare the products’ effects, try one for a full 90-day cycle, evaluate your results with documented blood glucose measurements, then make a decision about continuing or switching.
Are these supplements safe for people with type 2 diabetes?
Both products are dietary supplements, not medical treatments. They should not replace prescribed diabetes medications. People with type 2 diabetes who take metformin, insulin, sulfonylureas, GLP-1 agonists, or other glucose-lowering drugs need to discuss any supplement addition with their physician — berberine in particular has well-documented additive hypoglycemic effects with metformin, which can cause dangerously low blood glucose. These supplements are marketed as blood sugar support adjuncts, not treatments. The natural vs prescription blood sugar comparison article covers how supplements fit into the broader glycemic management picture.
How long does it take for either supplement to work?
Based on the clinical trial durations for the core ingredients, meaningful effects on fasting glucose and HbA1c require 8–12 weeks of consistent daily use at minimum. The landmark gymnema study required 18–24 months for maximum benefit. Neither supplement produces noticeable short-term blood sugar changes in the way a medication does. The right evaluation framework is: document your baseline fasting glucose (ideally with a glucometer or recent lab work), take the supplement consistently for 90 days, then compare. If you choose either product, commit to the full initial trial before evaluating whether to continue.
Do either Type 2 Protocol or Gluco6 cure type 2 diabetes?
No. Neither product is a diabetes cure, and neither is marketed as one. Both are dietary supplements intended to support healthy blood sugar levels and insulin sensitivity — they are adjuncts to lifestyle management, not medical interventions. Type 2 diabetes is a complex metabolic condition requiring physician-supervised care. These supplements may provide meaningful glycemic support as part of a comprehensive approach including diet, exercise, and medical oversight, but they do not address the underlying disease process independently.
Which supplement has a better refund policy?
Both Type 2 Protocol and Gluco6 are sold through ClickBank and carry 60-day money-back guarantees. The guarantee enforcement mechanism is identical — ClickBank’s buyer protection policy allows you to request a refund within 60 days of purchase whether or not the vendor responds. This makes both products equally low-risk to try: if the formula doesn’t work for you, your financial exposure is limited to the time window of the trial.
Check Current Pricing on the Official Type 2 Protocol Website{rel=“nofollow sponsored”} — 60-day money-back guarantee
A Note on Sugar Defender
If you’re actively comparing blood sugar supplements in 2026, it’s worth knowing that the Sugar Defender Review covers another ClickBank formula in this space that some buyers consider alongside Type 2 Protocol and Gluco6. Sugar Defender takes a different formulation approach, emphasizing energy and metabolic rate support alongside glycemic control. For buyers who specifically want a berberine-centered formula, Type 2 Protocol remains the strongest option in the category.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.